| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | ELECTRON TRANSFER IN PROTEINS |
| Discussion Leader: TBA |
| 7:40 pm - 8:20 pm | Harry B. Gray (Caltech, Pasadena, CA, USA)
"Electron flow through proteins" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Daniel G. Nocera (MIT, Cambridge, MA, USA)
"The road that radicals pave to the large scale deployment of solar energy" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | RIBONUCLEOTIDE REDUCTASES |
| Discussion Leader: J. Martin Bollinger, Jr. (Penn State University, University Park, PA, USA) |
| 9:00 am - 9:35 am | JoAnne Stubbe (MIT, Cambridge, MA, USA)
"Unnatural amino acids as probes of PCET: RNR as a paradigm" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | David R. Edgell (University of Western Ontario, London, ON, Canada)
"Assembly of a split ribonucleotide reductase by unique interaction domains" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:35 am | Astrid Gräslund (Stockholm University, Sweden)
"The iron-manganese cofactor in chlamydial ribonucleotide reductase and related proteins" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Per E.M. Siegbahn (Stockholm University, Sweden)
"Theoretical studies on ribonucleotide reductase" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEIN RADICAL MECHANISMS |
| Discussion Leader: James M. Whittaker (Oregon Health and Science University, Beaverton, OR, USA) |
| 7:30 pm - 8:05 pm | Nigel S. Scrutton (The University of Manchester, United Kingdom)
"Dynamics of hydride transfer in enzyme systems" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:50 pm | Brian M. Hoffman (Northwestern University, Evanston, IL, USA)
"Mechanistic implications of S-adenosylmethionine-dependent MoaA" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:30 pm | Poster Talks (TBA) |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CROSS-LINKED COFACTORS |
| Discussion Leader: Carrie M. Wilmot (University of Minnesota, Minneapolis, MN, USA) |
| 9:00 am - 9:35 am | Judith P. Klinman (University of California Berkeley, CA, USA)
"Quinocofactor biogenesis and function" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Victor L. Davidson (University of Mississippi, Jackson, MS, USA)
"A novel role for a diheme enzyme in tryptophan tryptophylquinone biosynthesis" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:35 am | Richard Magliozzo (Brooklyn College CUNY, Brooklyn, NY, USA)
"Role of the distal side Met-Tyr-Trp adduct in the catalase reaction of catalase-peroxidases" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:30 pm | Poster Talks (TBA) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | B12 ENZYMES AND RIBOSWITCHES |
| Discussion Leader: Michael J. McPherson (University of Leeds, United Kingdom) |
| 7:30 pm - 8:00 pm | Kurt Warncke (Emory University, Atlanta, GA, USA)
"Protein and Solvent Dynamical Contributions to Radical Generation and Rearrangement Reactions in B12 Enzymes" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Ruma V. Banerjee (University of Michigan Medical Center, Ann Arbor, MI, USA)
"The tinker, tailor and soldier in B12 trafficking" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Adam Roth (Yale University, New Haven, CT, USA)
"Riboswitch regulation of cofactor and coenzyme homeostasis" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RADICAL SAM PROTEINS |
| Discussion Leader: Carsten Krebs (Penn State University, University Park, PA, USA) |
| 9:00 am - 9:35 am | Diana M. Downs (University of Wisconsin, Madison, WI, USA)
"Characterization of ThiC from Salmonella enterica" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Steven E. Ealick (Cornell University, Ithaca, NY, USA)
"ThiC and Dph2 - two unpredicted SAM-dependent [4Fe-4S] enzymes" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:35 am | Joseph T. Jarrett (University of Hawaii Honolulu, HI, USA)
"Biotin synthase from Escherichia coli" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:30 pm | Poster Talks (TBA) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | RADICAL SAM PROTEINS |
| Discussion Leader: TBA |
| 7:30 pm - 8:05 pm | Joan B. Broderick (Montana State University, Bozeman, MT, USA)
"Novel reactions in the radical-SAM superfamily" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:50 pm | Squire J. Booker (Pennsylvania State University, University Park, PA, USA)
"Mechanistic insights into radical SAM dependent dehydrogenation reactions" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:30 pm | Poster Talks (TBA) |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | OXYGENASES AND IRON SULFUR PROTEINS |
| Discussion Leader: Simon E.V. Phillips (Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, Oxon, United Kingdom) |
| 9:00 am - 9:35 am | Emma L. Raven (University of Leicester, Leicester, United Kingdom)
"Mechanism and reactivity in the heme dioxygenase enzymes" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Roland Lill (Philipps-Universität Marburg, Germany)
"Function and biogenesis of iron-sulfur proteins" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:35 am | F. Wayne Outten (University of South Carolina, Columbia, SC, USA)
"Suf proteins and Fe-S cluster assembly pathways in bacteria" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:00 pm | Poster Talk: Pinghua Liu (Boston University, Boston, MA, USA)
"Mechanistic Studies of IspG and IspH in Prokaryotic Isoprenoid Biosynthesis" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:30 pm | Poster Talk (TBA) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HYDROGENASES |
| Discussion Leader: John W. Peters (Montana State University, Bozeman, MT, USA) |
| 7:30 pm - 8:10 pm | Marc Fontecave (iRTSV, Grenoble, France)
"Radical-SAM chemistry in hydrogenase maturation: a novel C-S bond formation mechanism" |
| 8:10 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:10 pm | Bärbel Friedrich (Humboldt University Berlin, Germany)
"Modifications of metal cofactors confer oxygen tolerance to NiFe hydrogenases" |
| 9:10 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |