Conference Program
 
Plasminogen Activation & Extracellular Proteolysis
February 14-19, 2010
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chairs:
Thomas H. Bugge & Vincent Ellis

Vice Chair:
Bradford S. Schwartz
Application Deadline
Applications for this meeting must be submitted by January 24, 2010. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Applications will still be accepted for oversubscribed meetings. However, they will only be considered by the Conference Chair if more seats become available due to cancellations.
Related Meeting Information
The Plasminogen Activation & Extracellular Proteolysis Gordon Research Conference will be held in conjunction with the Plasminogen Activation & Extracellular Proteolysis Gordon-Kenan Research Seminar. Those interested in attending both meetings must submit an application for the GKRS in addition to an application for the GRC. Please refer to the Plasminogen Activation & Extracellular Proteolysis GKRS web page for more information.

The plasminogen activation system and other proteolytic system that operate in the pericellular environment are essential regulators of cell signaling and extracellular matrix remodeling during development, homeostasis, tissue remodeling, and tissue regeneration. Furthermore, the aberrant activity of these proteolytic systems is intimately associated with the genesis or progression of some of the most important human diseases, including cardiovascular disease, central nervous system disorders, and cancer. With their extracellular location and documented causal roles in pathogenesis, these proteolytic systems provide excellent targets for pharmacological intervention aimed at improving human health. The GRC brings together the leading researchers in this area for a highly interactive and informative meeting in a casual atmosphere. Topics will include thrombolysis and fibrinolysis, vascular biology, central nervous system function and dysfunction, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, angiogenesis, and more.

Students and Postdoctoral Fellows will serve as Co-Discussion Leaders of all Sessions. Eight to ten talks will be selected from the submitted abstracts. The deadline for abstract submission is January 14, 2010. In addition to oral presentations, there will be two Poster Sessions that will feature prizes for best presentations by Students and Postdoctoral Fellows. Minorities can seek support for participation through a Carl Storm Underrepresented Minority Fellowship.

As a new feature, a Gordon-Kenan Research Seminar (GRS), specifically for Students and Postdoctoral Fellows within this field, will be held in immediate conjunction with the GRC. Please join us in 2010!

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThrombolysis, Fibrinolysis & Hemostasis
Discussion Leader: Nuala Booth (University of Aberdeen, United Kingdom)
7:35 pm - 7:40 pm Introduction
7:40 pm - 8:20 pm Bruce Beutler (Scripps Research Institute, La Jolla, California)
"Forward Genetics in the Mouse: from Phenotype to Function"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jay Degen (Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio)
"Thrombin and Inflammatory Processes"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Edward Plow (The Cleveland Clinic Foundation, Cleveland, Ohio)
"Regulation of Tailed and Untailed Plasminogen Receptors"
9:20 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCNS Function and Dysfunction
Discussion Leader: Katerina Akassoglou (Gladstone Institute of Neurological Disease, San Francisco, California)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am Katerina Akassoglou (Gladstone Institute of Neurological Disease, San Francisco, California)
"Molecular Determinants of Neurovascular Dynamics"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Robert Medcalf (Monash University, Melbourne, Australia)
"t-PA, the Blood Brain Barrier and Traumatic Brain Injury"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Daniel Lawrence (University of Michigan Medical School, Ann Arbor, Michigan)
"tPA and PDGF in the CNS"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Sidney Strickland (The Rockefeller University, New York, New York)
"A Possible Role for Fibrin in Alzheimer's Disease"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm J. Steven Jacobsen (Wyeth Research, Princeton, New Jersey)
"PAI-1 Inhibition and the Enhancement of Abeta Catabolism as a Therapeutic Strategy for the Treatment of Alzheimer's Disease"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCardiovascular Health and Disease
Discussion Leader: Qingyu Wu (The Cleveland Clinic Foundation, Cleveland, Ohio)
7:30 pm - 7:35 pm Introduction
7:35 pm - 8:00 pm Qingyu Wu (The Cleveland Clinic Foundation, Cleveland, Ohio)
"The Cardiac Membrane Protease Corin in Hypertensive and Heart Disease"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm David Dichek (University of Washington, Seattle, Washington)
"New Roles for uPA in Vascular Pathology"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Katherine Hajjar (Weill Medical College of Cornell University, New York, New York)
"The Annexin A2 System and Vascular Homeostasis"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInfection, Inflammation and Immunity
Discussion Leader: David Ginsburg (University of Michigan Medical School, Ann Arbor, Michigan)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am David Ginsburg (University of Michigan Medical School, Ann Arbor, Michigan)
"Hemostasis in Host Defense during Group A Streptococcal Infection"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Mark Walker (School of Biological Sciences, University of Wollongong, Wollongong, Australia)
"Interplay between Human Plasminogen, Wildtype and Hyperinvasive Group A streptococci"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Frank Castellino (University of Notre Dame, Notre Dame, Indiana)
"Mechanisms of Participation of Fibrinolytic System Components in Bacterial Pathogenesis"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Aime K. Zaas (Duke University Medical Center, Durham, North Carolina)
"Plasminogen Polymorphisms and Risk of Invasive Fungal Infection: A Case Study of Plasminogen's Role in Host Defense"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm Marcelo Jacobs-Lorena (Johns Hopkins School of Public Health, Baltimore, Maryland)
"Plasminogen plays a Critical Role for Development of the Malaria Parasite in its Mosquito Vector"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTissue Homeostasis & Regeneration
Discussion Leader: Toni Antalis (University of Maryland School of Medicine, Baltimore, Maryland)
7:30 pm - 7:35 pm Introduction
7:35 pm - 8:00 pm Toni Antalis (University of Maryland School of Medicine, Baltimore, Maryland)
"Membrane-Anchored Serine Proteases in Healing and Angiogenesis"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Andreas R. Janecke (Innsbruck Medical University, Innsbruck, Austria)
"Loss of Function of Serine Protease Inhibitor SPINT2 causes a Human Syndrome of Congenital Malformations and Sodium Diarrhea"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Pura Munoz-Canoves (University Pompeu Fabra and ICREA, Barcelona, Spain)
"The Plasminogen Activation/Fibrinolytic System in Muscular Dystrophy"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cell Biology & Hematopoiesis
Discussion Leader: Lindsay Miles (Scripps Research Institute, La Jolla, California)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am Karin Finberg (Duke University Medical Center, Durham, North Carolina)
"TMPRSS6: An Essential Regulator of Mammalian Iron Homeostasis"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Marc Tjwa (Goethe University & University Hospital Frankfurt, Frankfurt, Germany)
"Role of the Plasminogen System in the Regulation of Hematopoiesis"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Birgitte Rønø (Finsen Laboratory, Copenhagen, Denmark)
"Plasmin-mediated Fibrinolysis is Required for Hematopoietic Stem Cell Mobilization"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Peter Andreasen (University of Aarhus, Aarhus, Denmark)
"The Plasminogen Activation System in Bony Fish"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm TBA
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmLate Breaking Topics from Abstracts
Discussion Leaders: Vincent Ellis (University of East Anglia, Norfolk, United Kingdom) & Bradford Schwartz (University of Illinois, Urbana, Illinois)
7:30 pm - 7:40 pm TBA
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pm TBA
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm TBA
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm TBA
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm TBA
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm TBA
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm TBA
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm TBA
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTumor Biology and Angiogenesis
Discussion Leader: Sharon Stack (University of Missouri, Columbia, Missouri)
9:00 am - 9:05 am Introduction
9:05 am - 9:25 am Sharon Stack (University of Missouri, Columbia, Missouri)
"uPAR/Integrin Association and Altered MicroRNA Regulation in Oral Cancer"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 am Jim Quigley (Scripps Research Institute, La Jolla, California)
"Activation of uPA contributes functionally to Angiogenesis and the Dissemination of Human Fibrosarcoma and Prostate Carcinoma Cells"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 am Francesco Blasi (FIRC Institute of Molecular Oncology, Milan, Italy)
"Urokinase Receptor, Stem Cells and Cancer"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 am Steve Gonias (University of California, San Diego, California)
"uPAR-initiated Cell-signaling in Cancer"
11:40 am - 11:55 am Discussion
11:55 am - 12:15 pm Michael Ploug (Finsen Laboratory, Copenhagen, Denmark)
"The Urokinase Receptor. From Crystal Structure to in vivo Imaging"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:00 pmFree Time
5:00 pm - 6:00 pmFarewell Reception
6:00 pmDinner
7:30 pm - 9:30 pmProteases and Endocytic Receptors
Discussion Leader: Dan Lawrence (University of Michigan Medical School, Ann Arbor, Michigan)
7:30 pm - 7:35 pm Introduction
7:35 pm - 8:00 pm Dudley Strickland (University of Maryland School of Medicine, Baltimore, Maryland)
"Regulation of inflammation and vascular remodeling by LRP1"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Joyce Chan (Amgen Inc., South San Francisco, California)
"Targeting of the Serine Protease, PCSK9, for the Treatment of Hypercholesterolemia"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Niels Behrendt (Finsen Laboratory, Copenhagen, Denmark)
"The Composite Function of Proteolytic and Endocytic Processes in Matrix Turnover and Cancer Invasion"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: October 15, 2009